tpx [2019-06-26 08:20:49]

probable thiol peroxidase

locus: BSU29490

pI: 4.70

mw: 18.07 kDa

protein length: 167 aa

gene length: 504 bp

function: unknown

product: unknown

essential: no

synonyms: ytgI

Genomic Context

categories

• [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.8|Resistance against oxidative and electrophile stress]

Gene

Coordinates: 3,017,696 3,018,199

The protein

Protein family

• [SW|peroxiredoxin family] (according to Swiss-Prot)

Structure

• [PDB|2JSZ]

Expression and Regulation

Operons

• genes: [gene|2501228D435B151F151A3C0EF10DE99A8395977F|tpx]-[gene|2C83EECFA809F34ADCA6445CF2E6BAC730D523DB|ytxK]
  description: [Pubmed|22383849]

  regulatory mechanism

  • [protein|2C6386E9A63F410558D168798D077DF91590F454|Spx]: activation, [pubmed|12642660,19575568], in [regulon|2C6386E9A63F410558D168798D077DF91590F454|Spx regulon]

• genes: [gene|2501228D435B151F151A3C0EF10DE99A8395977F|tpx]
  description: [Pubmed|9387221]

  regulatory mechanism

  • [protein|2C6386E9A63F410558D168798D077DF91590F454|Spx]: activation, [Pubmed|12642660,19575568], in [regulon|2C6386E9A63F410558D168798D077DF91590F454|Spx regulon]

Biological materials

Mutant

• MGNA-A113 (ytgI::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/113 NBRP B. subtilis, Japan]
• BKE29490 ([gene|2501228D435B151F151A3C0EF10DE99A8395977F|tpx]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE29490 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTATAATTCCTCCCTTTT, downstream forward: _UP4_TAAGCAGGGAAAAAAGCTCC
• BKK29490 ([gene|2501228D435B151F151A3C0EF10DE99A8395977F|tpx]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK29490 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTATAATTCCTCCCTTTT, downstream forward: _UP4_TAAGCAGGGAAAAAAGCTCC

References

• 19636900,9387221,12642660